The design of EasyColumn manual chromatography column adheres to the innovative design concept. It adopts a special column head sealing method and a special column head rotation structure. It is easy to manually pack filler and need few supporting tools, and can provide fast manual packing for various chromatography media. This method saves time and reduces the operator's work intensity, and can also obtain accurate and highly reproducible column packing results, and coordinate the changeover of different product lines faster.