Principle of Current Bioreactor

Waves chase the beach, the torrents run thousands of miles. The beauty of science is born in nature along with tidal rise and fall. The single-use bioreactor of JYSS BIO also generates torrent through mechanical oscillation, which causes the culture liquid to wash the inner surface of the culture bag repeatedly, and causes the oxygen to dissolve rapidly. The gas is washed and towed through the culture medium to produce nanoscale soluble microbubbles, and the bubbles are constantly mixed so that each cell can get sufficient oxygen and nutrients, and maintain the normal growth and metabolism of cells. This new oxygen transfer mechanism effectively avoids the damage caused by the traditional bubbling and mechanical stirring mechanism, greatly improves the cell culture density, and significantly increases the production of virus and protein.

For adherent culture, JYSS BIO single-use bioreactor adopts an external circulation paper perfusion culture process to provide nutrients and dissolved oxygen for the cells, adjust and control DO, pH, temperature and other conditions online, and the culture medium meets the process requirements The flow rate is injected into the perfusion cell culture bag, and the same flow rate is returned to the dissolved oxygen system to form an external circulation paper perfusion culture mode. The paper sheet is used as a cell adsorption carrier and is fixed in the culture bag to take away cell metabolites, thereby forming a relatively stable fluid environment around the cells. This structure can provide a large specific surface area for cell adsorption and growth, achieving high-density cell culture purposes.

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